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In a new examine, we documented the identification along with the characterization of a new atypical opioid receptor with exclusive detrimental regulatory Qualities in the direction of opioid peptides.one Our effects confirmed that ACKR3/CXCR7, hitherto often known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a broad-spectrum scavenger for opioid peptides on the enkephalin, dynorphin, and nociceptin family members, regulating their availability for classical opioid receptors.

**This is a subjective assessment determined by the energy on the available informations and our estimation of efficacy.

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These effects, together with a former report displaying that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like habits in mice,2 assistance the principle of focusing on ACKR3 as a singular technique to modulate the opioid system, which could open new therapeutic avenues for opioid-connected disorders.